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Article

Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility.

Nature communications - 13 Sept 2021

Wen Wanqing, Chen Zhishan, Bao Jiandong, Long Quan, Shu Xiao-Ou, Zheng Wei, Guo Xingyi

Abstract excerpt

Identifying transcription factors (TFs) whose DNA bindings are altered by genetic variants that regulate susceptibility genes is imperative to understand transcriptional dysregulation in disease etiology. Here, we develop a statistical framework to analyze extensive ChIP-seq and GWAS data and identify 22 breast cancer risk-associated TFs. We find that, by analyzing genetic variations of TF-DNA bindings, the...

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Share to Chromatin
Share to DNA, Neoplasm
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Estrogen Receptor alpha

Share to Gene Regulatory Networks

Share to Hepatocyte Nuclear Factor 3-alpha

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Source

Open in PubMed Open full text

Identifiers

PMID: 34518541
DOI: 10.1038/s41467-021-25670-9
PMCID: PMC8438084

Genes

FOXA1
TF
E2F1
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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