Article
Integrative functional genomics identifies regulatory genetic variant modulating RAB31 expression and altering susceptibility to breast cancer.
Molecular carcinogenesis - 1 Dec 2018
Zhang Yi, Yang Beifang, Cheng Xiang, Liu Li, Zhu Ying, Gong Yajie, Yang Yang, Tian Jianbo, Peng Xiating, Zou Danyi, Yang Lan, Mei Shufang, Wang Xiaoyang, Lou Jiao, Ke Juntao, Li Jiaoyuan, Gong Jing, Chang Jiang, Yuan Peng, Zhong Rong
Abstract excerpt
Despite the successes of genome-wide association study (GWAS) in identifying breast cancer (BC) risk-associated variants, only a small fraction of the heritability can be explained. The greatest challenge in the post-GWAS is to identify causal variants and underlying mechanisms responsible for BC susceptibility. In this study, we integrated functional genomic data from ENCODE ChIP-seq, ANNOVAR, and the TRANSFAC...
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