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Article

Global transcription network incorporating distal regulator binding reveals selective cooperation of cancer drivers and risk genes.

Nucleic acids research - 13 Jul 2015

Kim Kwoneel, Yang Woojin, Lee Kang Seon, Bang Hyoeun, Jang Kiwon, Kim Sang Cheol, Yang Jin Ok, Park Seongjin, Park Kiejung, Choi Jung Kyoon

Abstract excerpt

Global network modeling of distal regulatory interactions is essential in understanding the overall architecture of gene expression programs. Here, we developed a Bayesian probabilistic model and computational method for global causal network construction with breast cancer as a model. Whereas physical regulator binding was well supported by gene expression causality in general, distal elements in intragenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26001967
DOI: 10.1093/nar/gkv532
PMCID: PMC4499150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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