Article
BRAF mutations may identify a clinically distinct subset of glioblastoma.
Scientific reports - 8 Oct 2021
McNulty Samantha N, Schwetye Katherine E, Ferguson Cole, Storer Chad E, Ansstas George, Kim Albert H, Gutmann David H, Rubin Joshua B, Head Richard D, Dahiya Sonika
Abstract excerpt
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Prior studies examining the mutational landscape of GBM revealed recurrent alterations in genes that regulate the same growth control pathways. To this regard, ~ 40% of GBM harbor EGFR alterations, whereas BRAF variants are rare. Existing data suggests that gain-of-function mutations in these genes are mutually exclusive. This study...
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