Molecular, histopathological, and genomic variants of glioblastoma.

Abstract excerpt

Glioblastoma (GBM), the most common primary brain tumor, has a poor median prognosis despite modern surgical, chemotherapeutic, and radiation modalities, which have shown little clinical efficacy. Initially categorized by clinicopathological classification into de novo primary GBM and secondary GBM, which arises from lower-grade glioma, genomic studies have elucidated several distinct genotypes. In addition,...

Topics

• Brain Neoplasms
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Glioblastoma
• Humans
• Molecular Targeted Therapy
• Mutation