Article
Characterization of molecular genetic alterations in GBMs highlights a distinctive molecular profile in young adults.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Dec 2011
Jha Prerana, Suri Vaishali, Singh Geetika, Jha Pankaj, Purkait Suvendu, Pathak Pankaj, Sharma Vikas, Sharma Mehar Chand, Suri Ashish, Gupta Deepak, Mahapatra Ashok Kumar, Sarkar Chitra
Abstract excerpt
To evaluate age-related differences in histopathologic and molecular profile of glioblastomas (GBMs) at various age groups, with special reference to TP53 mutation, epidermal growth factor receptor (EGFR) amplification, EGFR vIII mutant, PTEN deletion, and IDH1 mutation. Agewise GBM incidence was calculated over a period of 5 years (2005 to 2009). Seventy-five GBMs were selected for molecular analysis. Majority...
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