Glioblastoma: Biology, Genetics, and Behavior

Abstract excerpt

Glioblastoma (GBM) is a highly malignant, rapidly progressive astrocytoma that is distinguished pathologically from lower-grade tumors by necrosis and microvascular hyperplasia. The global pattern of growth changes dramatically with the development of GBM histology and is characterized by hypoxia-driven peripheral expansion from a growing necrotic core. Necrotic foci present centrally in GBM and are typically...