Article
Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma.
Journal of neuro-oncology - 1 May 2021
Lim-Fat Mary Jane, Song Kun Wei, Iorgulescu J Bryan, Andersen Brian M, Forst Deborah A, Jordan Justin T, Gerstner Elizabeth R, Reardon David A, Wen Patrick Y, Arrillaga-Romany Isabel
Abstract excerpt
PURPOSE: Although uncommon, detection of BRAF V600E mutations in adult patients with glioblastoma has become increasingly relevant given the widespread application of molecular diagnostics and encouraging therapeutic activity of BRAF/MEK inhibitors. METHODS: We performed a retrospective study of adult glioblastoma patients treated at Dana-Farber Cancer Institute/Brigham and Women's Hospital or Massachusetts...
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