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Comprehensive understanding of glioblastoma molecular phenotypes: classification, characteristics, and transition.

Cancer biology & medicine - 6 May 2024

Xu Can, Hou Pengyu, Li Xiang, Xiao Menglin, Zhang Ziqi, Li Ziru, Xu Jianglong, Liu Guoming, Tan Yanli, Fang Chuan

Abstract excerpt

Among central nervous system-associated malignancies, glioblastoma (GBM) is the most common and has the highest mortality rate. The high heterogeneity of GBM cell types and the complex tumor microenvironment frequently lead to tumor recurrence and sudden relapse in patients treated with temozolomide. In precision medicine, research on GBM treatment is increasingly focusing on molecular subtyping to precisely...

Topics

Humans
Glioblastoma
Phenotype
Brain Neoplasms
Gene Expression Regulation, Neoplastic
Tumor Microenvironment
Epithelial-Mesenchymal Transition
Biomarkers, Tumor

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38712813
DOI: 10.20892/j.issn.2095-3941.2023.0510
PMCID: PMC11131044

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