Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD)

Abstract excerpt

Cyst expansion in polycystic kidney disease (PKD) results in localized hypoxia in the kidney that may activate hypoxia-inducible factor-1α (HIF-1α). HIF-1α and autophagy, a form of programmed cell repair, are induced by hypoxia. The purposes were to determine HIF-1α expression and autophagy in rat and mouse models of PKD. HIF-1α was detected by electrochemiluminescence. Autophagy was visualized by electron...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biomedical Research and Pathophysiology
• Share to Epigenetics and DNA Methylation
• Share to Genetic and Kidney Cyst Diseases