Article
Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes.
Frontiers in immunology - 1 Jan 2021
Rivas Martin A, Durmaz Ceyda, Kloetgen Andreas, Chin Cristopher R, Chen Zhengming, Bhinder Bhavneet, Koren Amnon, Viny Aaron D, Scharer Christopher D, Boss Jeremy M, Elemento Olivier, Mason Christopher E, Melnick Ari M
Abstract excerpt
The cohesin complex plays critical roles in genomic stability and gene expression through effects on 3D architecture. Cohesin core subunit genes are mutated across a wide cross-section of cancers, but not in germinal center (GC) derived lymphomas. In spite of this, haploinsufficiency of cohesin ATPase subunit Smc3 was shown to contribute to malignant transformation of GC B-cells in mice. Herein we explored...
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