Article
MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis.
Cancer cell - 10 Sept 2018
Brescia Paola, Schneider Christof, Holmes Antony B, Shen Qiong, Hussein Shafinaz, Pasqualucci Laura, Basso Katia, Dalla-Favera Riccardo
Abstract excerpt
The gene encoding the MEF2B transcription factor is mutated in germinal center (GC)-derived B cell lymphomas, but its role in GC development and lymphomagenesis is unknown. We demonstrate that Mef2b deletion reduces GC formation in mice and identify MEF2B transcriptional targets in GC, with roles in cell proliferation, apoptosis, GC confinement, and differentiation. The most common lymphoma-associated MEF2B...
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