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Article

Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer.

Cancer research - 15 Dec 2021

Soshnev Alexey A, Allis C David, Cesarman Ethel, Melnick Ari M

Abstract excerpt

Aberrant cell fate decisions due to transcriptional misregulation are central to malignant transformation. Histones are the major constituents of chromatin, and mutations in histone-encoding genes are increasingly recognized as drivers of oncogenic transformation. Mutations in linker histone H1 genes were recently identified as drivers of peripheral lymphoid malignancy. Loss of H1 in germinal center B cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34580064
DOI: 10.1158/0008-5472.CAN-21-2619
PMCID: PMC8678342

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