Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.

doi:10.1038/s41586-020-3017-y

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Article

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.

Nature - 1 Jan 2021

Yusufova Nevin, Kloetgen Andreas, Teater Matt, Osunsade Adewola, Camarillo Jeannie M, Chin Christopher R, Doane Ashley S, Venters Bryan J, Portillo-Ledesma Stephanie, Conway Joseph, Phillip Jude M, Elemento Olivier, Scott David W, Béguelin Wendy, Licht Jonathan D, Kelleher Neil L, Staudt Louis M, Skoultchi Arthur I, Keogh Michael-Christopher, Apostolou Effie, Mason Christopher E, Imielinski Marcin, Schlick Tamar, David Yael, Tsirigos Aristotelis, Allis C David, Soshnev Alexey A, Cesarman Ethel, Melnick Ari M

Abstract excerpt

Linker histone H1 proteins bind to nucleosomes and facilitate chromatin compaction1, although their biological functions are poorly understood. Mutations in the genes that encode H1 isoforms B-E (H1B, H1C, H1D and H1E; also known as H1-5, H1-2, H1-3 and H1-4, respectively) are highly recurrent in B cell lymphomas, but the pathogenic relevance of these mutations to cancer and the mechanisms that are involved are...

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PMID: 33299181
DOI: 10.1038/s41586-020-3017-y
PMCID: PMC7855728

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