Article
Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.
The Lancet. Neurology - 1 Aug 2026
Lange Lara M, Fang Zih-Hua, Makarious Mary B, Kuznetsov Nicole, Atterling Brolin Kajsa, Ballard Shannon, Bardien Soraya, Doquenia Maria Leila, Heutink Peter, Houlden Henry, Iwaki Hirotaka, Jasaityte Simona, Jones Lietsel, Junker Johanna, Kaiyrzhanov Rauan, Koretsky Mathew J, Kumar Kishore R, Leonard Hampton L, Levine Kristin S, Lim Shen-Yang, Mencacci Niccoló E, Mohamed Wael M Y, Nalls Mike A, Noyce Alastair J, Ojha Rajeev, Okubadejo Njideka U, Ur Rehman Shoaib, Screven Laurel, Shashkin Chingiz, Sopromadze Sophia, Stafford Eleanor J, Tan Ai Huey, Tan Manuela, Tavadyan Zaruhi, Trinh Joanne, Tserensodnom Bayasgalan, Valente Enza Maria, Vitale Dan, Zharkinbekova Nazira, Lohmann Katja, Bandres-Ciga Sara, Blauwendraat Cornelis, Singleton Andrew B, Morris Huw R, Klein Christine
Abstract excerpt
BACKGROUND: The genetic architecture of Parkinson's disease varies considerably across ancestries, yet most previous genetic studies have focused on individuals of European ancestry. We aimed to characterise the distribution of established Parkinson's disease causal variants, as well as risk-associated variants with clinical implications (ie, variants in genes involved in pathways targeted by ongoing clinical...
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