Article
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Nature genetics - 1 Sept 2014
Nalls Mike A, Pankratz Nathan, Lill Christina M, Do Chuong B, Hernandez Dena G, Saad Mohamad, DeStefano Anita L, Kara Eleanna, Bras Jose, Sharma Manu, Schulte Claudia, Keller Margaux F, Arepalli Sampath, Letson Christopher, Edsall Connor, Stefansson Hreinn, Liu Xinmin, Pliner Hannah, Lee Joseph H, Cheng Rong, Ikram M Arfan, Ioannidis John P A, Hadjigeorgiou Georgios M, Bis Joshua C, Martinez Maria, Perlmutter Joel S, Goate Alison, Marder Karen, Fiske Brian, Sutherland Margaret, Xiromerisiou Georgia, Myers Richard H, Clark Lorraine N, Stefansson Kari, Hardy John A, Heutink Peter, Chen Honglei, Wood Nicholas W, Houlden Henry, Payami Haydeh, Brice Alexis, Scott William K, Gasser Thomas, Bertram Lars, Eriksson Nicholas, Foroud Tatiana, Singleton Andrew B
Abstract excerpt
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.