Article
A systematic analysis of genetic interactions and their underlying biology in childhood cancer.
Communications biology - 6 Oct 2021
Daub Josephine T, Amini Saman, Kersjes Denise J E, Ma Xiaotu, Jäger Natalie, Zhang Jinghui, Pfister Stefan M, Holstege Frank C P, Kemmeren Patrick
Abstract excerpt
Childhood cancer is a major cause of child death in developed countries. Genetic interactions between mutated genes play an important role in cancer development. They can be detected by searching for pairs of mutated genes that co-occur more (or less) often than expected. Co-occurrence suggests a cooperative role in cancer development, while mutual exclusivity points to synthetic lethality, a phenomenon of...
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