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Article

A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer.

BMC medical genomics - 12 Dec 2025

Spinou Anastasia, Gremmen Richard, Drost Jarno, Kemmeren Patrick

Abstract excerpt

BACKGROUND: The exponential increase of sequenced cancer genomes has enabled the in-silico study of genetic interactions in tumors across many cancer types—particularly synthetic lethality, where two gene alterations lead to cell death—and identify new candidate therapeutic targets. This rise is primarily present in adult cancer, while in-silico investigation of genetic interactions remains challenging in...

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Identifiers

PMID: 41388546
DOI: 10.1186/s12920-025-02289-z
PMCID: PMC12822016

Genes

DROSHA
TP53

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