Article

Functional genomic analysis of adult and pediatric brain tumor isolates

2023-01-06

Abstract excerpt

<h4>Background</h4> Adult and pediatric tumors display stark differences in their mutation spectra and chromosome alterations. Here, we attempted to identify common and unique gene dependencies and their associated biomarkers among adult and pediatric tumor isolates using functional genetic lethal screens and computational modeling. <h4>Methods</h4> We performed CRISRP-Cas9 lethality screens in two adult gliobla...

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Literature Corpus work: 2b3a2798-c07e-5b58-90ef-5fe640dbc016
DOI: 10.1101/2023.01.05.522885

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