Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deep Genetic Connection Between Cancer and Developmental Disorders.

Human mutation - 1 Oct 2016

Qi Hongjian, Dong Chengliang, Chung Wendy K, Wang Kai, Shen Yufeng

Abstract excerpt

Cancer and developmental disorders (DDs) share dysregulated cellular processes such as proliferation and differentiation. There are well-known genes implicated in both in cancer and DDs. In this study, we aim to quantify this genetic connection using publicly available data. We found that among DD patients, germline damaging de novo variants are more enriched in cancer driver genes than non-drivers. We estimate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Databases, Genetic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Mutation, Missense

Share to Neoplasms

Share to Neurodevelopmental Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 27363847
DOI: 10.1002/humu.23040
PMCID: PMC5021574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deep Genetic Connection Between Cancer and Developmental Disorders.PMID 27363847Read ↗

Germline mutations in cancer predisposition genes among pediatric patients with cancer and congenital anomalies.Semantic proximity Read ↗

Integrating healthcare and research genetic data empowers the discovery of 28 novel developmental disordersSemantic proximity Read ↗

Integrating healthcare and research genetic data empowers the discovery of 49 novel developmental disordersSemantic proximity Read ↗

Prevalence and architecture of de novo mutations in developmental disorders.Semantic proximity Read ↗

Prevalence, phenotype and architecture of developmental disorders caused by <i>de novo</i> mutation: The Deciphering Developmental Disorders StudySemantic proximity Read ↗

Hereditary Conditions Associated with Elevated Cancer Risk in Childhood.Semantic proximity Read ↗

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.Semantic proximity Read ↗

Federated analysis of the contribution of recessive coding variants to 29,745 developmental disorder patients from diverse populationsSemantic proximity Read ↗

Using somatic data to aid germline clinical variant interpretation in developmental disordersSemantic proximity Read ↗

The genetic era of childhood cancer: Identification of high-risk patients and germline sequencing approaches.Semantic proximity Read ↗

Prevalence and Clinical Significance of Adult-Onset Cancer Predisposition Variants in Pediatric OncologySemantic proximity Read ↗

The genetics and genomics of cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.