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Article

Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation.

The Journal of cell biology - 6 Dec 2021

Clay Delisa E, Bretscher Heidi S, Jezuit Erin A, Bush Korie B, Fox Donald T

Abstract excerpt

Cycling cells must respond to DNA double-strand breaks (DSBs) to avoid genome instability. Missegregation of chromosomes with DSBs during mitosis results in micronuclei, aberrant structures linked to disease. How cells respond to DSBs during mitosis is incompletely understood. We previously showed that Drosophilamelanogaster papillar cells lack DSB checkpoints (as observed in many cancer cells). Here, we show...

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Source

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Identifiers

PMID: 34613334
DOI: 10.1083/jcb.202106116
PMCID: PMC8500225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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