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Article

Apolipoprotein E Genotype Contributes to Motor Progression in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2022

Pu Jia-Li, Jin Chong-Yao, Wang Zhong-Xuan, Fang Yi, Li Yao-Lin, Xue Nai-Jia, Zheng Ran, Lin Zhi-Hao, Yan Yi-Qun, Si Xiao-Li, Chen Ying, Liu Yi, Song Zhe, Yan Ya-Ping, Tian Jun, Yin Xin-Zhen, Zhang Bao-Rong

Abstract excerpt

BACKGROUND: Emerging evidence indicates that the apolipoprotein E (APOE) ε4 exacerbates α-synuclein pathology. OBJECTIVE: To determine whether APOE ε4 contributes to motor progression in early Parkinson's disease (PD). METHODS: Longitudinal data were obtained from 384 patients with PD divided into APOE ε4 carriers (n = 85) and noncarriers (n = 299) in the Parkinson's Progression Marker Initiative. Participants...

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Identifiers

PMID: 34612548
DOI: 10.1002/mds.28805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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