Article
GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study.
Movement disorders : official journal of the Movement Disorder Society - 1 May 2022
Szwedo Aleksandra A, Dalen Ingvild, Pedersen Kenn Freddy, Camacho Marta, Bäckström David, Forsgren Lars, Tzoulis Charalampos, Winder-Rhodes Sophie, Hudson Gavin, Liu Ganqiang, Scherzer Clemens R, Lawson Rachael A, Yarnall Alison J, Williams-Gray Caroline H, Macleod Angus D, Counsell Carl E, Tysnes Ole-Bjørn, Alves Guido, Maple-Grødem Jodi
Abstract excerpt
BACKGROUND: Common genetic variance in apolipoprotein E (APOE), β-glucocerebrosidase (GBA), microtubule-associated protein tau (MAPT), and α-synuclein (SNCA) has been linked to cognitive decline in Parkinson's disease (PD), although studies have yielded mixed results. OBJECTIVES: To evaluate the effect of genetic variants in APOE, GBA, MAPT, and SNCA on cognitive decline and risk of dementia in a pooled analysis...
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