Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Physical Activity and APOE Genotype With Longitudinal Cognitive Change in Early Parkinson Disease.

Neurology - 11 May 2021

Kim Ryul, Park Sangmin, Yoo Dallah, Jun Jin-Sun, Jeon Beomseok

Abstract excerpt

OBJECTIVE: To determine whether greater physical activity could modify the negative association of APOE ε4 with longitudinal cognitive changes in early Parkinson disease (PD) and to uncover the disease-specific mechanism for explaining such benefits of physical activity. METHODS: We used data from the Parkinson's Progression Markers Initiative cohort. Because self-reported physical activity, measured by the...

Topics

Join the communities discussing this publication.

Aged
Apolipoprotein E4
Cognitive Dysfunction
Cohort Studies
Exercise

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

Parkinson Disease

Source

Identifiers

PMID: 33790041
DOI: 10.1212/WNL.0000000000011852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Physical Activity and APOE Genotype With Longitudinal Cognitive Change in Early Parkinson Disease.PMID 33790041Read ↗

Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review.Semantic proximity Read ↗

Ten-year longitudinal effects of physical activity and apolipoprotein E ..4 genotype on precuneus atrophy in Japanese older adults.Semantic proximity Read ↗

The role of APOE in cognitive trajectories and motor decline in Parkinson's disease.Semantic proximity Read ↗

Association analyses of Apolipoprotein E genotypes and cognitive performance in patients with Parkinson’s diseaseSemantic proximity Read ↗

Alzheimer's disease prevention: Apolipoprotein e4 moderates the effect of physical activity on brain beta-amyloid deposition in healthy older adults.Semantic proximity Read ↗

Impact of the apolipoprotein E ε4 allele on early Parkinson's disease progression.Semantic proximity Read ↗

Apolipoprotein E Genotype Contributes to Motor Progression in Parkinson's Disease.Semantic proximity Read ↗

Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson's disease.Semantic proximity Read ↗

Association analyses of apolipoprotein E genotypes and cognitive performance in patients with Parkinson's disease.Semantic proximity Read ↗

Physical Activity, APOE Genotype, and Cognitive Decline: Exploring Gene-Environment Interactions in the UK BiobankSemantic proximity Read ↗

Age-Related Association Between APOE ɛ4 and Cognitive Progression in de novo Parkinson's Disease.Semantic proximity Read ↗

Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.