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Article

Age-Related Association Between APOE ɛ4 and Cognitive Progression in de novo Parkinson's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Liu Jia-Yao, Ma Ling-Zhi, Wang Jun, Cui Xin-Jing, Sheng Ze-Hu, Fu Yan, Li Meng, Ou Ya-Nan, Yu Jin-Tai, Tan Lan, Lian Yan

Abstract excerpt

BACKGROUND: APOE ɛ4 genotype was correlated with exacerbation of pathology and higher risk of dementia in Parkinson's disease (PD). Meanwhile, the differential influence of APOE ɛ4 on cognition in young and old individuals interpreted as antagonistic pleiotropy. OBJECTIVE: To examine whether the effect of APOE ɛ4 on cognitive progression in de novo PD is age dependent. METHODS: In this study, 613 de novo PD...

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Aged
Apolipoprotein E4
Cognition
Cognitive Dysfunction
Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

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PMID: 36565124
DOI: 10.3233/JAD-220976

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