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Article

Impact of the apolipoprotein E ε4 allele on early Parkinson's disease progression.

Parkinsonism & related disorders - 1 Feb 2021

Kim Ryul, Park Sangmin, Yoo Dallah, Jun Jin-Sun, Jeon Beomseok

Abstract excerpt

OBJECTIVE: Emerging evidence shows that apolipoprotein E (APOE) ε4 exacerbates alpha-synuclein pathology. We aimed to investigate whether the APOE ε4 allele contributes to early Parkinson's disease (PD) progression. METHODS: This cohort study included 361 early PD patients who were classified as APOE ε4 carriers (n = 90) and noncarriers (n = 271). The patients underwent yearly motor and nonmotor assessments...

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Identifiers

PMID: 33484977
DOI: 10.1016/j.parkreldis.2021.01.004

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