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Article

Apolipoprotein E Polymorphism Is Associated with Age of Onset and Neuropathology in Colony Stimulating Factor 1 Receptor-Related Disorder.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2026

Chmiela Tomasz, Roemer Shanu, Strongosky Audrey J, Baker Matthew C, Dickson Dennis W, Wszolek Zbigniew K

Abstract excerpt

BACKGROUND: Colony stimulating factor 1 receptor-related disorder (CSF1R-RD) is a rare, rapidly progressive neurodegenerative disease with significant clinical heterogeneity. Apolipoprotein E (ApoE) polymorphism, known to modulate microglial function and influence neurodegeneration, may act as a genetic modifier in CSF1R-RD. OBJECTIVES: The objectives were to evaluate the distribution of ApoE alleles in CSF1R-RD...

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Identifiers

PMID: 41518624
DOI: 10.1002/mds.70192

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CSF1R

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