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APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression.

Journal of Parkinson's disease - 2 Apr 2016

Paul Kimberly C, Rausch Rebecca, Creek Michelle M, Sinsheimer Janet S, Bronstein Jeff M, Bordelon Yvette, Ritz Beate

Abstract excerpt

BACKGROUND: Cognitive decline is well recognized in Parkinson's disease (PD) and a major concern for patients and caregivers. Apolipoprotein E (APOE), catechol-O-methyl transferase (COMT), and microtubule-associated protein tau (MAPT) are of interest related to their contributions to cognitive decline or dementia in PD. OBJECTIVE: Here, we investigate whether APOE, COMT, or MAPT influence the rate of cognitive...

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Aged
Apolipoproteins E
Catechol O-Methyltransferase
Cognition
Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 27061069
DOI: 10.3233/JPD-150762
PMCID: PMC5927361

Genes

COMT
APOE
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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