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Article

Inhibition of CDK9 activity compromises global splicing in prostate cancer cells

30 Sept 2021

Abstract excerpt

Cyclin-dependent kinase 9 (CDK9) phosphorylates RNA polymerase II to promote productive transcription elongation. Here we show that short-term CDK9 inhibition affects the splicing of thousands of mRNAs. CDK9 inhibition impairs global splicing and there is no evidence for a coordinated response between the alternative splicing and the overall transcriptome. Alternative splicing is a feature of aggressive prostate...

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Identifiers

PMID: 34592899
DOI: 10.1080/15476286.2021.1983287

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