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Article

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer

29 Oct 2018

Abstract excerpt

BACKGROUND: Liquid biopsies have demonstrated that the constitutively active androgen receptor splice variant-7 (AR-V7) associates with reduced response and overall survival from endocrine therapies in castration-resistant prostate cancer (CRPC). However, these studies provide little information pertaining to AR-V7 expression in prostate cancer (PC) tissue. METHODS: Following generation and validation of a...

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PMID: 30334814
DOI: 10.1172/jci122819

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