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Article

Splicing Factors Have an Essential Role in Prostate Cancer Progression and Androgen Receptor Signaling

1 Apr 2019

Abstract excerpt

Although inhibition of the androgen⁻androgen receptor (AR) axis effectively represses the growth of prostate cancer, most of all cases eventually become castration-resistant prostate cancers (CRPCs). Enhancement of the expression of AR and its variants along with the downstream signals is important for disease progression. AR-V7, a constitutive active form of AR, is generated as a result of RNA splicing. RNA...

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PMID: 30939845
DOI: 10.3390/biom9040131

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