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Article

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

3 Sept 2019

Abstract excerpt

Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet also control pre-mRNA splicing through less clear mechanisms. Here we find androgens regulate splicing through AR-mediated transcriptional control of the...

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PMID: 31478829
DOI: 10.7554/elife.47678

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