Article

Compromised CDK12 activity causes dependency on the non-essential spliceosome components

2021-12-09

Abstract excerpt

Prostate cancer (PC) is the most common cancer in men and after development of the castration-resistant PC (CRPC), there are no curative treatment options. Inactivating mutations in cyclin-dependent kinase 12 (CDK12) define an aggressive sub-type of CRPC. We hypothesized that compromised CDK12 activity leads to significant rewiring of the CRPC cells, and that this rewiring results in actionable synthetic lethal in...

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Literature Corpus work: bf6da9ac-ba98-5078-9ec3-3523aec9f152
DOI: 10.1101/2021.12.07.470703

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