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Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer

30 Sept 2024

Abstract excerpt

Resistance to androgen receptor (AR)-targeted therapies represents a major challenge in prostate cancer. A key mechanism of treatment resistance in patients who progress to castration-resistant prostate cancer (CRPC) is the generation of alternatively spliced AR variants (AR-V). Unlike full-length AR isoforms, AR-Vs are constitutively active and refractory to current receptor-targeting agents and hence drive...

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Mass Spectrometry Techniques and Applications
Prostate Cancer Treatment and Research
RNA Research and Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39348093
DOI: 10.1158/1541-7786.mcr-23-0958

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