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Article

Targeting the CLK 2/ SRSF 9 splicing axis in prostate cancer leads to decreased ARV 7 expression

11 Sept 2024

Abstract excerpt

In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency. Androgen receptor splice variant-7 (ARV7) is clinically the most relevant and has a distinct 3' untranslated region (3'UTR) compared to the AR full-length variant, suggesting a unique post-transcriptional...

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PMID: 39258426
DOI: 10.1002/1878-0261.13728

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