Article

Androgen-regulated transcription of <i>ESRP2</i> drives alternative splicing patterns in prostate cancer

2019-05-08

Abstract excerpt

Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet also control pre-mRNA splicing through less clear mechanisms. Here we find androgens regulate splicing through AR-mediated transcriptional control of the epithelial-spec...

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Literature Corpus work: f609ae25-339f-5762-bfa9-9760f9119429
DOI: 10.1101/629618

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