Article
A protein interaction landscape of breast cancer.
Science (New York, N.Y.) - 1 Oct 2021
Kim Minkyu, Park Jisoo, Bouhaddou Mehdi, Kim Kyumin, Rojc Ajda, Modak Maya, Soucheray Margaret, McGregor Michael J, O'Leary Patrick, Wolf Denise, Stevenson Erica, Foo Tzeh Keong, Mitchell Dominique, Herrington Kari A, Muñoz Denise P, Tutuncuoglu Beril, Chen Kuei-Ho, Zheng Fan, Kreisberg Jason F, Diolaiti Morgan E, Gordan John D, Coppé Jean-Philippe, Swaney Danielle L, Xia Bing, van 't Veer Laura, Ashworth Alan, Ideker Trey, Krogan Nevan J
Abstract excerpt
Cancers have been associated with a diverse array of genomic alterations. To help mechanistically understand such alterations in breast-invasive carcinoma, we applied affinity purification–mass spectrometry to delineate comprehensive biophysical interaction networks for 40 frequently altered breast cancer (BC) proteins, with and without relevant mutations, across three human breast cell lines. These networks...
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