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Article

BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling.

Scientific reports - 15 Mar 2022

Bradbury Melissa, Borràs Eva, Castellví Josep, Méndez Olga, Sánchez-Iglesias José Luis, Pérez-Benavente Assumpció, Gil-Moreno Antonio, Sabidó Eduard, Santamaria Anna

Abstract excerpt

Despite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis with the addition of valuable ubiquitination profiling, and their dependency on BRCA1 mutation-state directly in patient-derived tissues. Using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35292711
DOI: 10.1038/s41598-022-08461-0
PMCID: PMC8924168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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