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Article

Identification of target proteins for breast cancer genetic risk loci and blood risk biomarkers in a large study by integrating genomic and proteomic data.

International journal of cancer - 1 Jun 2023

Jia Guochong, Yang Yaohua, Ping Jie, Xu Shuai, Liu Lili, Guo Xingyi, Tao Ran, Long Jirong, Zheng Wei

Abstract excerpt

Genome-wide association studies (GWAS) have identified around 200 loci associated with breast cancer risk. However, protein targets for these loci remain largely unknown. Identifying protein targets and biomarkers can improve the understanding of cancer biology and etiology and identify high-risk individuals for cancer prevention. In this study, we investigated genetically predicted levels of 1142 circulating...

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PMID: 36779764
DOI: 10.1002/ijc.34472
PMCID: PMC10079603

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