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Article

A proteome-wide association study identifies putative causal proteins for breast cancer risk.

British journal of cancer - 1 Dec 2024

Zhao Tianying, Xu Shuai, Ping Jie, Jia Guochong, Dou Yongchao, Henry Jill E, Zhang Bing, Guo Xingyi, Cote Michele L, Cai Qiuyin, Shu Xiao-Ou, Zheng Wei, Long Jirong

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function. In this study, we conducted a proteome-wide association study (PWAS) to identify proteins in breast tissue related to breast cancer risk. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39468330
DOI: 10.1038/s41416-024-02879-1
PMCID: PMC11589835

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