Article

Differential Remodeling of the BRCA1 Interactome by a Unique Minimal Clinical Truncation Mutation

2024-12-02

Abstract excerpt

BRCA1, a critical tumor suppressor gene, plays an essential role in maintaining genomic stability through its involvement in DNA double-strand break repair, particularly via homologous recombination. Loss or impairment of BRCA1 function disrupts this repair pathway, resulting in genomic instability and significantly increased susceptibility to breast and ovarian cancers. To elucidate the molecular mechanisms by wh...

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Literature Corpus work: 1409a9f8-5fa6-5015-8159-11545f2b2cb6
DOI: 10.1101/2024.11.26.625539

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