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PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes

13 Jun 2017

Abstract excerpt

Breast cancer (BC) is a highly heterogeneous disease, both at the pathological and molecular level, and several chromatin-associated proteins play crucial roles in BC initiation and progression. Here, we demonstrate the role of PSIP1 (PC4 and SF2 interacting protein)/p75 (LEDGF) in BC progression. PSIP1/p75, previously identified as a chromatin-adaptor protein, is found to be upregulated in basal-like/triple...

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PMID: 28633434
DOI: 10.1093/carcin/bgx062

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