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Article

Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.

Scientific reports - 29 Sept 2021

Sun-Wada Ge-Hong, Tabata Hiroyuki, Wada Yoh

Abstract excerpt

The endocytic compartments keep their interior acidic through the inward flow of protons and anions from the cytosol. Acidification is mediated by a proton pump known as vacuolar-type ATPase (V-ATPase) and transporters conferring anion conductance to the organellar membrane. In this study, we analysed the phenotype of mouse embryos lacking the V-ATPase c-subunit. The mutant embryos differentiated embryonic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34588579
DOI: 10.1038/s41598-021-98952-3
PMCID: PMC8481250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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