Article
Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms?
Biochimica et biophysica acta - 1 Oct 2010
Lee Sun-Kyung, Li Weixun, Ryu Seong-Eon, Rhim Taiyoun, Ahnn Joohong
Abstract excerpt
Vacuolar (H(+))-ATPases, also called V-ATPases, are ATP-driven proton pumps that are highly phylogenetically conserved. Early biochemical and cell biological studies have revealed many details of the molecular mechanism of proton pumping and of the structure of the multi-subunit membrane complex, including the stoichiometry of subunit composition. In addition, yeast and mouse genetics have broadened our...
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