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Article

The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila.

Developmental cell - 1 Sept 2009

Yan Yan, Denef Natalie, Schüpbach Trudi

Abstract excerpt

We have identified Rabconnectin-3alpha and beta (Rbcn-3A and B) as two regulators of Notch signaling in Drosophila. We found that, in addition to disrupting Notch signaling, mutations in Rbcn-3A and B cause defects in endocytic trafficking, where Notch and other membrane proteins accumulate in late endosomal compartments. We show that Notch is transported to the surface of mutant cells and that signaling is...

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Share to Adaptor Proteins, Signal Transducing
Share to Adenosine Triphosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Fluorescence

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Source

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Identifiers

PMID: 19758563
DOI: 10.1016/j.devcel.2009.07.001
PMCID: PMC2758249

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