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Article

The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor.

Development (Cambridge, England) - 1 Jun 2010

Vaccari Thomas, Duchi Serena, Cortese Katia, Tacchetti Carlo, Bilder David

Abstract excerpt

Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that regulate Notch activation in endosomes, we isolated mutants in Drosophila genes that encode subunits of the vacuolar ATPase (V-ATPase) proton pump. Cells lacking V-ATPase function display impaired acidification of the endosomal compartment and a correlated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20460366
DOI: 10.1242/dev.045484
PMCID: PMC2867318

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