Article
Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms.
Journal of bioenergetics and biomembranes - 1 Feb 2008
Wada Yoh, Sun-Wada Ge-Hong, Tabata Hiroyuki, Kawamura Nobuyuki
Abstract excerpt
Acidification inside membrane compartments is a common feature of all eukaryotic cells. The acidic milieu is involved in many physiological processes including secretion, protein processing, and others. However, its cellular relevance has not been well established beyond the results of in vitro studies involving cultured cell systems. In the last decade, human and mouse genetics have revealed that the...
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