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Article

Mutations in vacuolar H+ -ATPase subunits lead to biliary developmental defects in zebrafish.

Developmental biology - 15 May 2012

EauClaire Steven F, Cui Shuang, Ma Liyuan, Matous James, Marlow Florence L, Gupta Tripti, Burgess Harold A, Abrams Elliott W, Kapp Lee D, Granato Michael, Mullins Mary C, Matthews Randolph P

Abstract excerpt

We identified three zebrafish mutants with defects in biliary development. One of these mutants, pekin (pn), also demonstrated generalized hypopigmentation and other defects, including disruption of retinal cell layers, lack of zymogen granules in the pancreas, and dilated Golgi in intestinal epithelial cells. Bile duct cells in pn demonstrated an accumulation of electron dense bodies. We determined that the...

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Identifiers

PMID: 22465374
DOI: 10.1016/j.ydbio.2012.03.009
PMCID: PMC3337356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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