Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

29 Sept 2021

Abstract excerpt

-Jac), associated with healthy brain aging and reduced risk for AD and dementia with Lewy bodies (DLB). Herein, we resolved the functional mechanism by which APOE3-Jac reduces APOE aggregation and enhances its lipidation in human brains, as well as in cellular and biochemical assays. Compared to APOE3, expression of APOE3-Jac in astrocytes increases several classes of lipids in the brain including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholesterol and Lipid Metabolism
Share to Natural Antidiabetic Agents Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34586832
DOI: 10.1126/scitranslmed.abc9375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementiaPMID 34586832Read ↗

High-density lipoprotein mimetic peptide 4F ameliorates APOE4-associated lipid dysfunction in primary and iPSC-derived astrocytes and cerebral organoidsSemantic proximity Read ↗

ApoE Lipidation as a Therapeutic Target in Alzheimer’s DiseaseSemantic proximity Read ↗

<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsSemantic proximity Read ↗

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.Semantic proximity Read ↗

Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches.Semantic proximity Read ↗

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue ModelSemantic proximity Read ↗

APOE3 Christchurch is associated with sphingolipids recycling and glial lipid remodeling in autosomal dominant Alzheimer’s diseaseSemantic proximity Read ↗

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesisSemantic proximity Read ↗

Recombinant sialylated ApoE2 suppresses ApoE4 and sex-specifically strengthens brain metabolism and cognition in ApoE4 miceSemantic proximity Read ↗

APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neuronsSemantic proximity Read ↗

APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition.Semantic proximity Read ↗

ApoE lipidation, not isoform, is the key modulator of Aβ interaction, uptake, and cytotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.