Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches.

Current Alzheimer research - 1 Oct 2009

Zhong Ning, Weisgraber Karl H

Abstract excerpt

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease (AD) by an as yet to be defined mechanism. Since the structure or biophysical properties of a protein directly determines function, our approach to addressing mechanism is structure:function based. Domain interaction a structural property of apoE4 that distinguishes it from apoE3 is predicted to contribute to the association of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E4
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Neurons

Share to Protein Conformation

Share to Protein Folding

Share to Protein Structure, Tertiary

Source

Open in PubMed Open full text

Identifiers

PMID: 19874264
DOI: 10.2174/156720509789207921
PMCID: PMC2810311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches.PMID 19874264Read ↗

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse modelsSemantic proximity Read ↗

Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.Semantic proximity Read ↗

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic StrategiesSemantic proximity Read ↗

ApoE Lipidation as a Therapeutic Target in Alzheimer’s DiseaseSemantic proximity Read ↗

Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein ESemantic proximity Read ↗

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDSSemantic proximity Read ↗

Detrimental Effects of Apolipoprotein E4: Potential Therapeutic Targets in Alzheimers DiseaseSemantic proximity Read ↗

The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventionsSemantic proximity Read ↗

APOEε4 and risk of Alzheimer’s disease – time to move forwardSemantic proximity Read ↗

Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele.Semantic proximity Read ↗

Human apolipoprotein E: the Alzheimer's disease connection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.